Cross-Coupling Reactions: Suzuki, Heck, Sonogashira and Stille
Organometallics · Entrance Exams Cross-Coupling Reactions: Suzuki, Heck, Sonogashira and Stille Four named couplings that share one palladium cycle — and differ only in what supplies the second carbon fragment. BSc & MSc · Organometallic Chemistry · Concept The short answer: All four couplings run on the same three-step palladium cycle. Oxidative addition and reductive elimination are common to every one of them; what distinguishes Suzuki, Sonogashira and Stille is only which organometallic delivers the partner group. The Heck is the exception — it has no transmetalation at all, and that single difference explains its different substrate scope and its…